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Anatomy & Physiology

Body systems, medical terminology, and disease processes relevant to clinical practice.

9% of NHA CCMA exam·50 practice questions

Anatomy & Physiology covers 9% of the CCMA exam. Questions test body system structure and function, medical terminology, and disease processes relevant to clinical practice. The exam will not require memorizing every anatomical detail, but you must know the major organs of each system, their functions, and common conditions associated with each.

Medical Terminology — Word Parts

Medical terms are built from a prefix (before the root, modifies meaning), word root/combining form (the core meaning, often an organ), and suffix (after the root, often indicates a procedure or condition). Examples: cardio (heart) + megaly (enlargement) = cardiomegaly. Common prefixes: tachy (fast), brady (slow), hyper (above normal), hypo (below normal), poly (many), oligo (few). Common suffixes: -itis (inflammation), -ectomy (surgical removal), -oscopy (visual examination), -plasty (surgical repair), -emia (blood condition). When analyzing a term, start with the suffix.

Start with the suffix when analyzing an unfamiliar medical term — it tells you what type of word it is.

Key Body Systems and Their Functions

Cardiovascular: heart pumps blood; SA node is the primary pacemaker (60–100 bpm); AV node is the backup (40–60 bpm); coronary arteries supply the myocardium. Respiratory: alveoli are the gas exchange sites; surfactant prevents alveolar collapse. Endocrine: pancreas secretes insulin (lowers blood glucose) and glucagon (raises blood glucose); thyroid secretes T3/T4 (metabolism). Renal: kidneys filter ~180 L of plasma/day; nephron is the functional unit; ADH controls water reabsorption. Neurological: ANS has sympathetic (fight-or-flight) and parasympathetic (rest-and-digest) divisions.

Common Disease Processes

Type 1 diabetes: autoimmune destruction of beta cells, requires insulin; DKA is the acute complication. Type 2 diabetes: insulin resistance; managed with lifestyle + oral agents ± insulin; HHNS is the acute hyperglycemic complication. Hypertension: BP ≥130/80 mmHg per ACC/AHA 2017 guidelines; Stage 2 ≥140/90. COPD: irreversible airflow obstruction; emphysema destroys alveolar walls; chronic bronchitis = productive cough ≥3 months/year for 2 consecutive years. CHF: left heart failure = pulmonary edema (crackles, dyspnea); right heart failure = peripheral edema, JVD, ascites.

Must-Know for the Exam

  • Analyze medical terms starting with the suffix, then root, then prefix
  • -itis=inflammation, -ectomy=removal, -oscopy=visual exam, -plasty=repair, -emia=blood condition
  • SA node: primary pacemaker 60–100 bpm; AV node backup 40–60 bpm
  • Insulin lowers blood glucose; glucagon raises it — both from the pancreas
  • Hypertension: ≥130/80 (Stage 1), ≥140/90 (Stage 2) per ACC/AHA
  • Left heart failure → pulmonary edema; right heart failure → peripheral edema
  • Type 1 DM: no insulin production, requires insulin therapy; DKA is acute complication
  • COPD: emphysema destroys alveoli; chronic bronchitis = productive cough 3+ months × 2 years

Common Exam Mistakes

  • Starting analysis with the prefix instead of the suffix
  • Confusing tachycardia (fast) with bradycardia (slow)
  • Mixing up left vs. right heart failure signs (pulmonary vs. peripheral edema)
  • Confusing DKA (Type 1) with HHNS (Type 2) acute complications
  • Using old BP cutoffs — hypertension is now ≥130/80, not ≥140/90

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Key Concepts — Part 1

1. A patient's chart notes a lesion on the anterior aspect of the tibia. This location refers to which area?

The front of the lower leg

Anterior means toward the front of the body, and the tibia is the larger bone of the lower leg (shin). The back of the thigh would be the posterior femoral region, the side of the ankle is lateral, and the bottom of the foot is the plantar surface.

2. A medical assistant is decoding the term 'hepatomegaly' in a patient's chart. What does this term mean?

Enlargement of the liver

The root 'hepat/o' means liver and the suffix '-megaly' means enlargement. Inflammation would be 'hepatitis' (-itis), removal would be 'hepatectomy' (-ectomy), and disease would be 'hepatopathy' (-pathy).

3. A provider asks the medical assistant to place a patient in the prone position for a back examination. How should the patient be positioned?

Lying face down on the abdomen

Prone position means lying face down on the abdomen, which provides access to the posterior body. Lying face up is supine, lying on the left side with knees bent is Sims' position, and sitting upright is Fowler's position.

4. Which layer of the skin contains blood vessels, hair follicles, and sweat glands?

Dermis

The dermis is the middle layer of skin and contains blood vessels, nerves, hair follicles, sebaceous glands, and sweat glands. The epidermis is the outermost avascular layer, the subcutaneous layer (hypodermis) is primarily fat and connective tissue, and the stratum corneum is the outermost sublayer of the epidermis.

5. An elderly bedridden patient develops a reddened, non-blanchable area over the sacrum. This is most consistent with what condition?

Stage 1 pressure ulcer

A Stage 1 pressure ulcer presents as intact skin with non-blanchable redness, typically over bony prominences like the sacrum in immobile patients. Contact dermatitis usually involves itching and a rash from an irritant, psoriasis presents as silvery scaly plaques, and basal cell carcinoma appears as a pearly nodule often with telangiectasias.

6. A patient presents with pain and inflammation of the fluid-filled sac that cushions the shoulder joint. This condition is called:

Bursitis

Bursitis is inflammation of a bursa, the fluid-filled sac that cushions joints. Tendinitis is inflammation of a tendon, arthritis is inflammation of a joint itself, and myositis is inflammation of muscle tissue.

7. A postmenopausal woman is diagnosed with a condition characterized by decreased bone density and increased fracture risk. This condition is:

Osteoporosis

Osteoporosis is characterized by loss of bone density, making bones porous and fragile, and is common in postmenopausal women due to decreased estrogen. Osteoarthritis is joint cartilage degeneration, osteomyelitis is a bone infection, and osteomalacia is softening of bones due to vitamin D deficiency.

8. A patient arrives at the clinic with sudden onset of right-sided facial droop, slurred speech, and weakness in the right arm. These symptoms most likely indicate:

Stroke (CVA)

Sudden onset of unilateral facial droop, slurred speech, and arm weakness are hallmark signs of a stroke (CVA), matching the FAST assessment. MS typically has a progressive relapsing-remitting course, Parkinson's presents with tremor and bradykinesia, and peripheral neuropathy causes tingling/numbness in extremities, usually bilaterally.

9. Which chamber of the heart pumps oxygenated blood to the systemic circulation?

Left ventricle

The left ventricle pumps oxygenated blood through the aorta to the systemic circulation. The right atrium receives deoxygenated blood from the body, the right ventricle pumps blood to the lungs, and the left atrium receives oxygenated blood from the lungs.

10. A patient's blood pressure is consistently 148/94 mmHg over multiple visits. According to current guidelines, this is classified as:

Stage 2 hypertension

A blood pressure of 148/94 falls into Stage 2 hypertension (systolic ≥140 or diastolic ≥90). Normal is <120/<80, elevated is 120-129/<80, and Stage 1 is 130-139/80-89.

Key Concepts — Part 2

1. During gas exchange, oxygen and carbon dioxide are exchanged between the blood and air in which structures of the lungs?

Alveoli

Gas exchange occurs across the thin walls of the alveoli, tiny air sacs surrounded by capillaries. The bronchi and bronchioles are conducting airways, and the trachea is the main windpipe—none of these participate in gas exchange.

2. A patient with a long history of smoking presents with chronic productive cough, dyspnea, and barrel chest. This clinical picture is most consistent with:

COPD

COPD (chronic obstructive pulmonary disease) is strongly associated with smoking and presents with chronic productive cough, dyspnea, and barrel chest from air trapping. Asthma is typically episodic with wheezing, PE presents acutely with sudden dyspnea and chest pain, and TB usually presents with night sweats, weight loss, and hemoptysis.

3. A patient reports frequent heartburn, especially after meals and when lying down. This is most consistent with:

Gastroesophageal reflux disease (GERD)

GERD is characterized by reflux of stomach acid into the esophagus, causing heartburn that worsens after meals and when lying down. Peptic ulcers typically cause epigastric pain related to eating, Crohn's causes chronic diarrhea and abdominal pain, and appendicitis causes acute right lower quadrant pain.

4. Which structure of the nephron is responsible for filtering blood to form the initial filtrate?

Glomerulus

The glomerulus is a network of capillaries within Bowman's capsule where blood is filtered to form the initial filtrate. The loop of Henle concentrates urine, the collecting duct performs final water reabsorption, and the distal convoluted tubule handles further reabsorption and secretion.

5. A 24-year-old female presents with dysuria, urinary frequency, and suprapubic discomfort. These symptoms most likely indicate:

Urinary tract infection (UTI)

Dysuria (painful urination), frequency, and suprapubic discomfort are classic symptoms of a lower UTI (cystitis), which is common in young women. Kidney stones typically cause severe flank pain radiating to the groin, CKD is usually asymptomatic early on, and bladder cancer typically presents with painless hematuria.

6. An older male patient reports difficulty starting urination, weak urine stream, and nocturia. These symptoms are most consistent with:

Benign prostatic hyperplasia (BPH)

BPH causes urinary hesitancy, weak stream, and nocturia due to non-cancerous prostate enlargement compressing the urethra, and is very common in older men. Prostate cancer is often asymptomatic early on, testicular torsion causes acute severe testicular pain, and epididymitis causes scrotal pain and swelling.

7. A patient with type 1 diabetes presents with polyuria, polydipsia, polyphagia, and unexplained weight loss. These symptoms result from:

Insufficient insulin production

Type 1 diabetes results from autoimmune destruction of pancreatic beta cells, leading to insufficient insulin production and the classic '3 Ps' plus weight loss. Excess insulin would cause hypoglycemia, excess thyroid hormone causes hyperthyroidism symptoms, and insufficient cortisol causes Addison's disease.

8. A patient presents with weight gain, cold intolerance, fatigue, constipation, and dry skin. These symptoms are most consistent with:

Hypothyroidism

Hypothyroidism causes a slowed metabolism, resulting in weight gain, cold intolerance, fatigue, constipation, and dry skin. Hyperthyroidism causes the opposite (weight loss, heat intolerance), Cushing's causes moon face and central obesity from excess cortisol, and Addison's causes hyperpigmentation and hypotension.

9. A patient reports gradual, painless loss of central vision and cloudy or blurry vision. This is most consistent with:

Cataracts

Cataracts cause gradual clouding of the lens, resulting in painless blurry or cloudy vision, especially in older adults. Glaucoma typically affects peripheral vision first due to increased intraocular pressure, otitis media is an ear infection, and conjunctivitis causes red irritated eyes with discharge.

10. A medical assistant sees the abbreviation 'PRN' on a medication order. What does this indicate?

As needed

PRN comes from the Latin 'pro re nata,' meaning 'as needed.' 'By mouth' is PO, 'twice daily' is BID, and 'before meals' is AC (ante cibum).

Key Concepts — Part 3

1. A CMA is reviewing a chart that includes the term 'hepatomegaly.' What does this term indicate?

Enlargement of the liver

The suffix '-megaly' means enlargement, and 'hepat/o' is the combining form for liver, so hepatomegaly means enlargement of the liver. Inflammation would be hepatitis (-itis), removal would be hepatectomy (-ectomy), and disease would be hepatopathy (-pathy).

2. A patient is lying face down on the examination table. This position is best described as:

Prone

Prone position means lying face down on the abdomen. Supine is lying face up, lateral recumbent is lying on the side, and Fowler's position is a seated position with the head of the bed elevated.

3. A CMA is assisting with a procedure that requires dividing the body into anterior (front) and posterior (back) sections. Which anatomical plane accomplishes this?

Frontal (coronal) plane

The frontal or coronal plane divides the body into anterior and posterior portions. The sagittal plane divides into left and right, the transverse plane divides into upper and lower, and the midsagittal plane specifically divides into equal left and right halves.

4. A patient presents with a stage 2 pressure ulcer on the sacrum. Which layer of skin is affected at this stage?

Partial-thickness loss involving the epidermis and/or dermis

A stage 2 pressure ulcer involves partial-thickness skin loss with damage to the epidermis and/or dermis, often presenting as a shallow open ulcer or blister. Stage 1 shows non-blanchable erythema with intact skin, stage 3 involves subcutaneous tissue, and stage 4 exposes bone, tendon, or muscle.

5. An elderly patient reports a wrist fracture after a minor fall. The provider suspects a condition characterized by decreased bone density. This condition is:

Osteoporosis

Osteoporosis is characterized by decreased bone density leading to fragile bones and increased fracture risk, especially in postmenopausal women and elderly patients. Osteoarthritis is joint cartilage degeneration, osteomyelitis is bone infection, and osteomalacia is softening of bones from vitamin D deficiency.

6. A patient arrives with sudden onset of unilateral facial drooping, slurred speech, and right arm weakness. The CMA should recognize these as signs of:

Stroke (CVA)

Sudden facial drooping, slurred speech, and unilateral weakness are classic signs of a stroke (CVA), assessed using the FAST acronym (Face, Arms, Speech, Time). MS typically has a gradual, relapsing course; Parkinson's presents with tremor and rigidity; Alzheimer's causes progressive memory loss.

7. During a cardiac cycle, which heart chamber pumps oxygenated blood to the systemic circulation?

Left ventricle

The left ventricle pumps oxygenated blood through the aorta to the systemic circulation. The right atrium receives deoxygenated blood from the body, the right ventricle pumps blood to the lungs, and the left atrium receives oxygenated blood from the lungs.

8. A patient with a long history of smoking presents with chronic cough, dyspnea, and barrel chest. Pulmonary function tests show airflow limitation. This is most consistent with:

COPD

COPD is characterized by chronic cough, dyspnea, and barrel chest resulting from long-term smoking and irreversible airflow limitation. Asthma is typically reversible and episodic; PE presents acutely with sudden chest pain and dyspnea; TB usually presents with hemoptysis, night sweats, and weight loss.

9. A patient reports burning epigastric pain that worsens after meals and when lying down, along with a sour taste in the mouth. These symptoms most likely indicate:

Gastroesophageal reflux disease (GERD)

GERD causes burning epigastric or retrosternal pain (heartburn) that worsens after meals and when supine, often with regurgitation causing a sour taste. Appendicitis causes RLQ pain, Crohn's causes chronic diarrhea and abdominal pain, and cirrhosis presents with jaundice and ascites.

10. A CMA is collecting a urine specimen from a patient with suspected UTI. Which structure is responsible for filtering blood to form urine?

Nephron

The nephron is the functional unit of the kidney where blood filtration and urine formation occur. The ureters transport urine from kidneys to bladder, the bladder stores urine, and the urethra carries urine out of the body.

Key Concepts — Part 4

1. A 55-year-old male reports difficulty starting urination, weak stream, and frequent nighttime urination. These symptoms are most consistent with:

Benign prostatic hyperplasia (BPH)

BPH causes urinary hesitancy, weak stream, and nocturia due to enlargement of the prostate compressing the urethra, common in men over 50. Prostate cancer is often asymptomatic early on, UTIs cause dysuria and urgency, and kidney stones cause severe flank pain.

2. A patient with type 1 diabetes mellitus requires insulin because:

The pancreatic beta cells produce little to no insulin

Type 1 diabetes is an autoimmune condition where pancreatic beta cells are destroyed, resulting in little or no insulin production, requiring lifelong insulin therapy. Insulin resistance describes type 2 diabetes, and the other options do not accurately describe type 1 diabetes pathophysiology.

3. A patient presents with fatigue, weight gain, cold intolerance, dry skin, and constipation. The provider orders a TSH test. These symptoms are most consistent with:

Hypothyroidism

Hypothyroidism causes a slowed metabolism resulting in fatigue, weight gain, cold intolerance, dry skin, and constipation. Hyperthyroidism causes the opposite symptoms (weight loss, heat intolerance), Cushing's causes moon face and truncal obesity, and Addison's causes hyperpigmentation and hypotension.

4. A patient with glaucoma is being educated about their condition. The CMA should explain that glaucoma is characterized by:

Increased intraocular pressure damaging the optic nerve

Glaucoma is characterized by increased intraocular pressure that damages the optic nerve, potentially causing blindness if untreated. Clouding of the lens describes cataracts, middle ear inflammation is otitis media, and retinal detachment is a separate condition.

5. The combining form 'cardi/o' combined with the suffix '-itis' creates a term meaning:

Inflammation of the heart

The suffix '-itis' means inflammation, so carditis means inflammation of the heart. Enlargement would use '-megaly' (cardiomegaly), study of would use '-logy' (cardiology), and disease would use '-pathy' (cardiopathy).

6. A CMA notes a patient's chart states 'BP 158/96 mmHg' on three separate visits. According to standard guidelines, this indicates:

Stage 2 hypertension

Stage 2 hypertension is defined as systolic BP ≥140 mmHg or diastolic ≥90 mmHg, so 158/96 falls in stage 2. Normal is <120/80, elevated is 120-129/<80, and stage 1 is 130-139/80-89 mmHg.

7. Which blood component is primarily responsible for transporting oxygen throughout the body?

Red blood cells (erythrocytes)

Red blood cells (erythrocytes) contain hemoglobin, which binds and transports oxygen from the lungs to tissues. Platelets are involved in clotting, white blood cells fight infection, and plasma is the liquid portion that transports various substances but not oxygen primarily.

8. A child presents with ear pain, fever, and tugging at the ear. The tympanic membrane appears red and bulging. This is most consistent with:

Otitis media

Otitis media is a middle ear infection common in children, presenting with ear pain, fever, and a red, bulging tympanic membrane. Otitis externa is inflammation of the ear canal, Ménière's involves vertigo and hearing loss, and presbycusis is age-related hearing loss.

9. During inhalation, the diaphragm:

Contracts and moves downward

During inhalation, the diaphragm contracts and flattens (moves downward), increasing thoracic cavity volume and decreasing pressure to draw air into the lungs. During exhalation, it relaxes and moves upward, decreasing thoracic volume to push air out.

10. A CMA is documenting that a wound is located on the palm side of the patient's hand. The correct directional term for this location is:

Palmar

Palmar refers specifically to the palm side of the hand. Dorsal refers to the back of the hand or the posterior of the body, ventral refers to the front of the body in general, and plantar refers to the sole of the foot.

Key Concepts — Part 5

1. A patient's chart notes a lesion on the anterior surface of the leg, distal to the knee. Which directional description matches this location?

On the front of the leg, below the knee

Anterior means the front of the body, and distal means farther from the point of attachment (in this case, below the knee toward the foot). Posterior refers to the back, proximal means closer to the point of attachment, and lateral refers to the side.

2. A CMA is documenting a patient's diagnosis of inflammation of the liver. Which medical term should be recorded?

Hepatitis

Hepatitis combines the root 'hepat/o' (liver) with the suffix '-itis' (inflammation). Nephritis is inflammation of the kidney, hepatomegaly is enlargement of the liver, and cholecystitis is inflammation of the gallbladder.

3. An elderly bedridden patient develops a reddened, non-blanching area over the sacrum. This finding is most consistent with which condition?

Stage 1 pressure ulcer

A Stage 1 pressure ulcer presents as intact skin with non-blanchable redness, typically over a bony prominence like the sacrum in immobile patients. Psoriasis appears as silvery scaly plaques, contact dermatitis follows exposure to an irritant, and basal cell carcinoma appears as a pearly nodule, often on sun-exposed areas.

4. A 68-year-old postmenopausal woman is diagnosed with a condition characterized by decreased bone density and increased fracture risk. Which disorder does this describe?

Osteoporosis

Osteoporosis is characterized by decreased bone mass and density, making bones porous and fragile, and is common in postmenopausal women due to estrogen loss. Osteoarthritis is joint cartilage degeneration, osteomyelitis is bone infection, and rheumatoid arthritis is an autoimmune joint disease.

5. A patient presents with sudden onset right-sided facial droop, slurred speech, and weakness of the right arm. The CMA should recognize these signs as consistent with which condition?

Cerebrovascular accident (stroke)

Sudden unilateral facial droop, slurred speech, and arm weakness are classic FAST warning signs of a stroke (CVA). Parkinson's presents with gradual tremor and rigidity, MS causes progressive neurological deficits over time, and Alzheimer's presents with progressive memory loss, not sudden focal deficits.

6. During a cardiac exam, the CMA is asked to identify the chamber of the heart that pumps oxygenated blood to the systemic circulation. Which chamber is this?

Left ventricle

The left ventricle pumps oxygenated blood through the aorta to the systemic circulation and has the thickest myocardial wall due to this workload. The right atrium receives deoxygenated blood, the right ventricle pumps to the lungs, and the left atrium receives oxygenated blood from the pulmonary veins.

7. A patient with a long history of smoking presents with chronic productive cough, dyspnea on exertion, and barrel chest. Which condition is most likely?

COPD

COPD is strongly associated with long-term smoking and presents with chronic productive cough, progressive dyspnea, and barrel chest from air trapping. Asthma is typically episodic with reversible bronchospasm, PE presents with sudden pleuritic pain and dyspnea, and TB typically causes hemoptysis, night sweats, and weight loss.

8. A patient reports burning epigastric pain that worsens after meals and when lying down. Which condition is most likely?

GERD

GERD (gastroesophageal reflux disease) causes burning epigastric or retrosternal pain (heartburn) that worsens after eating and when supine due to acid reflux into the esophagus. Appendicitis causes RLQ pain, Crohn's typically causes chronic diarrhea and abdominal cramping, and cirrhosis presents with jaundice and ascites.

9. A patient with type 1 diabetes mellitus asks the CMA why they require insulin injections. Which explanation is most accurate?

The beta cells of the pancreas do not produce insulin

Type 1 diabetes results from autoimmune destruction of the pancreatic beta cells, causing an absolute lack of insulin production, so exogenous insulin is required. Type 2 diabetes involves insulin resistance, and the thyroid gland does not directly regulate blood glucose.

10. An older patient reports gradual painless loss of vision described as 'looking through cloudy glass.' Which condition is most consistent with this description?

Cataracts

Cataracts cause a gradual, painless clouding of the lens, producing blurred or hazy vision commonly described as looking through cloudy or frosted glass. Glaucoma involves increased intraocular pressure with peripheral vision loss, otitis media is a middle ear infection unrelated to vision, and macular detachment is not a standard medical term (retinal detachment causes sudden vision changes).

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